Hydrochloric Acid → HCID 131710905, compound

HRID 2072464Notes

Reaction equation

HRID 2072464 reaction equation
[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][C@H:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[CH:24]=5)[C@H:19]4[OH:30])[CH2:13][CH2:12]3)[C:10](=[O:31])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>CCOCC>[ClH:32].[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][C@H:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[CH:24]=5)[C@H:19]4[OH:30])[CH2:13][CH2:12]3)[C:10](=[O:31])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22799507HCID 22799507, compound

Product 1

HCID 131710905HCID 131710905, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-Phenyl-8-[(cis-1,2,3,4-tetrahydro-1-hydroxy-6-methoxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]-decan-4-one (2.5 g) is suspended in 100 ml of anhydrous ether and treated with one equivalent of etheral hydrogen chloride. The resulting mixture is stirred at room temperature for one hour and then cooled. The precipitate is collected and washed with additional ether to yield 2.1 g of the title compound, melting point 243°-244° C.

Workup

  1. temperaturecooled
  2. customThe precipitate is collected
  3. washwashed with additional ether

Sources & evidence

ORD record
ord-598725dd706f484f989adff040045d76
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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