HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 8-[(3,4-Dihydro-2-naphthalenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide | HCID 21408223 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-[(3,4-Dihydro-2-naphthalenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | HCID 21408212 | — |
Reaction Conditions
| Temperature | 170 °C |
|---|
Reaction Steps
A mixture of 1-[(3,4-dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide (5.0 g) and formamide (18 g) is heated for 12 hours at 170° C. The reaction mixture is cooled, diluted with water (100 ml), and extracted with chloroform. The chloroform solution is dried over sodium sulfate and concentrated to give crude product. Trituration with ethyl acetate produces the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04051248 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-9d18760453b047a1b98f888caa04b72a |
| Source note | uspto-grants-1977_09 |