反应详情

A mixture of 1-[(3,4-dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide (6.0 g), triethyl orthoformate (3.0 g), toluene (30 ml), and glacial acetic acid (1.5 ml) is refluxed under nitrogen for 38 hours. The reaction mixture is cooled and poured into aqueous ammonium hydroxide. The organic layer is separated, dried, and concentrated to give the crude product. Digestion of this material with benzene followed by filtration and concentration of the organic solution yields the title compound.

1. temperatureis refluxed under nitrogen for 38 hours
2. temperatureThe reaction mixture is cooled
3. customThe organic layer is separated
4. customdried
5. concentrationconcentrated
6. customto give the crude product
7. filtrationDigestion of this material with benzene followed by filtration and concentration of the organic solution