Hydrochloric Acid → 1-[(1,2,3,4-Tetrahydro-1-oxo-2-naphthalenyl)-methyl]-4-anilino isonipecotamide, hydrochloride

HRID 2072479Notes

Reaction equation

HRID 2072479 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[CH2:12][N:13]1[CH2:21][CH2:20][C:16]([NH:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]([NH2:19])=[O:18])[CH2:15][CH2:14]1.[ClH:29]>C(O)C>[ClH:29].[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[CH2:12][N:13]1[CH2:21][CH2:20][C:16]([NH:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)([C:17]([NH2:19])=[O:18])[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 214082001-[(1,2,3,4-Tetrahydro-1-oxo-2-naphthalenyl)methyl]-4-anilino isonipecotamide

Product 1

HCID 1317109071-[(1,2,3,4-Tetrahydro-1-oxo-2-naphthalenyl)-methyl]-4-anilino isonipecotamide, hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Finely-ground 1-[(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-methyl]-4-anilino isonipecotamide (5.0 g) is slurried in absolute ethanol and treated with 1.2 equivalents of ethereal hydrogen chloride. The resulting mixture is cooled and filtered to yield the title compound.

Workup

  1. temperatureThe resulting mixture is cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-2bc12515b42e4c3983136af42078d2b0
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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