1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → HCID 21408202, compound

HRID 2072497Notes

Reaction equation

HRID 2072497 reaction equation
Cl.[CH3:2][N:3]([CH2:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][C:10]([CH3:17])=[C:11]([CH3:16])[CH:12]=2)[C:7]1=[O:18])[CH3:4].[C:19]1([N:25]2[C:29]3([CH2:34]CNC[CH2:30]3)[C:28](=[O:35])[NH:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[C:19]1([N:25]2[C:29]3([CH2:30][CH2:2][N:3]([CH2:5][CH:6]4[CH2:15][CH2:14][C:13]5[C:8](=[CH:9][C:10]([CH3:17])=[C:11]([CH3:16])[CH:12]=5)[C:7]4=[O:18])[CH2:4][CH2:34]3)[C:28](=[O:35])[NH:27][CH2:26]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 22104533HCID 22104533, compound

Product 1

HCID 21408202HCID 21408202, compoundYield 80.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 14.0 g of 2-[(dimethylamino)methyl]-3,4-dihydro-6,7-dimethyl-1(2H)-naphthalenone, hydrochloride, 13.1 g of 92% 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one and 250 ml of absolute ethanol is warmed on a steam bath for 1 hour and then stirred vigorously for 14 hours. The resulting precipitates are collected and washed with absolute ethanol to give 17.6 g of the title compound, melting point 182°-183° C.

Workup

  1. temperatureis warmed on a steam bath for 1 hour
  2. customThe resulting precipitates
  3. customare collected
  4. washwashed with absolute ethanol

Sources & evidence

ORD record
ord-ff2253a182834ad695cc5532a96cbc3d
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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