1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → HCID 21408202, compound

Participants

Reaction Steps

A mixture of 14.0 g of 2-[(dimethylamino)methyl]-3,4-dihydro-6,7-dimethyl-1(2H)-naphthalenone, hydrochloride, 13.1 g of 92% 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one and 250 ml of absolute ethanol is warmed on a steam bath for 1 hour and then stirred vigorously for 14 hours. The resulting precipitates are collected and washed with absolute ethanol to give 17.6 g of the title compound, melting point 182°-183° C.

Provenance & Evidence