HCID 19859542, compound → HCID 19858782, compound

HRID 2072626Notes

Reaction equation

HRID 2072626 reaction equation
[CH3:1][CH:2]([CH2:18][CH3:19])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[CH:13][C:14]([OH:17])=[N:15][CH:16]=2)=[CH:7][CH:6]=1.[F:20][C:21]1[CH:29]=[C:28]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:27]=[CH:26][C:22]=1[C:23](Cl)=[O:24]>N1C=CC=CC=1>[F:20][C:21]1[CH:29]=[C:28]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:27]=[CH:26][C:22]=1[C:23]([O:17][C:14]1[CH:13]=[N:12][C:11]([C:8]2[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH:2]([CH3:1])[CH2:18][CH3:19])=[CH:6][CH:7]=2)=[CH:16][N:15]=1)=[O:24]

Participants

4

Reactant 2

HCID 19859542HCID 19859542, compoundHCID 178446912HCID 178446912, compound

Product 1

HCID 19858782HCID 19858782, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

8.0 mmol of 5-[4-(2-methylbutoxy)-phenyl]-2-pyrazinol (known from Japanese Preliminary Published Application 92,276/'85) are added with stirring to a mixture of 7.0 mmol of 2-fluoro-4-octylbenzoyl chloride and 5 ml of pyridine and left to stand overnight. This gives optically active (S) 2-(2-fluoro-4-octylbenzoyloxy)-5-[4-(2-methylbutoxy)-phenyl]-pyrazine after extraction with toluene (30 ml) and water (20 ml), working up of the toluene phase and subsequent distillation.

Workup

  1. waitleft

Sources & evidence

ORD record
ord-8dd2d140022e4406ae00a5ce062ed2d2
Source dataset
uspto-grants-1990_04
Patent number
US04913837

Reaction notes

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