HCID 19859542, compound → HCID 19858782, compound

Participants

Reaction Steps

8.0 mmol of 5-[4-(2-methylbutoxy)-phenyl]-2-pyrazinol (known from Japanese Preliminary Published Application 92,276/'85) are added with stirring to a mixture of 7.0 mmol of 2-fluoro-4-octylbenzoyl chloride and 5 ml of pyridine and left to stand overnight. This gives optically active (S) 2-(2-fluoro-4-octylbenzoyloxy)-5-[4-(2-methylbutoxy)-phenyl]-pyrazine after extraction with toluene (30 ml) and water (20 ml), working up of the toluene phase and subsequent distillation.

Provenance & Evidence