反应详情

To a solution of glycine ethyl ester hydrochloride (22 g) and potassium carbonate (86 g) in water (600 ml) was added a mixture of benzene (600 ml) and ether (400 ml) and stirred at room temperature. 2-Thenoyl chloride (25 g) in benzene (100 ml) was added during a period of about 30 minutes under stirring and then the mixture was stirred for 2 hours at room temperature. The organic layer was separated and after dried over anhydrous sodium sulfate, concentrated under reduced pressure to give colorless crystals, which were recrystallized from ethanol to obtain the objective compound (23 g), mp 82°-83° C.

1. stirringunder stirring
2. stirringthe mixture was stirred for 2 hours at room temperature
3. customThe organic layer was separated
4. dry with materialafter dried over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure
6. customto give colorless crystals, which
7. customwere recrystallized from ethanol