反应详情

温度

60 °C

To a solution of sodium (1.4 g) in ethanol (120 ml) was added malonamide (3.8 g) and the mixture was heated at 60° C. for an hour under stirring. Then after added N-(2-thenoyl)glycine ethyl ester (8 g), the mixture was refluxed for 6 hours. The mixture was concentrated to give the residue which was diluted with water. The aqueous mixture was neutralized by adding acetic acid to deposit a crystalline product which was collected by filtration and recrystallized from dimethylformamide (DMF) to give the objective product (2.8 g) as colorless crystals, mp 270°-275° C. (decompd.).

1. temperaturethe mixture was refluxed for 6 hours
2. concentrationThe mixture was concentrated
3. customto give the residue which
4. filtrationwas collected by filtration
5. customrecrystallized from dimethylformamide (DMF)