Aluminum(III) Chloride → HCID 14773363, compound

HRID 2072693Notes

Reaction equation

HRID 2072693 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:11][O:12][C:13]1[CH:29]=[CH:28][C:16]([C:17]([C:19]2[CH:20]=[C:21]([S:24]([NH2:27])(=[O:26])=[O:25])[S:22][CH:23]=2)=O)=[CH:15][CH:14]=1>C1COCC1>[CH3:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:17][C:19]2[CH:20]=[C:21]([S:24]([NH2:27])(=[O:26])=[O:25])[S:22][CH:23]=2)=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 6451240Aluminum(III) ChlorideHCID 146390694-(4-Methoxybenzoyl)thiophene-2-sulfonamideHCID 21226445Aluminium lithium hydride

Product 1

HCID 14773363HCID 14773363, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent3×

Conditions

Temperature
60 °C

Procedure

To a solution of 0.667 g (0.005 mol) aluminum chloride in 10 ml THF at 0°-10° C. was added a solution of 0.19 g (0.005 mol) lithium aluminum hydride in 10 ml THF dropwise. Then, a solution of 0.6 g (0.002 mol) 4-(4-methoxybenzoyl)thiophene-2-sulfonamide in 10 ml THF was added dropwise and the resulting mixture was heated at 60° C. overnight at which time all starting material was consumed. The cooled reaction mixture was quenched with saturated aqueous sodium potassium tartrate solution and the resulting grey solid was filtered off. The filtrate was dried and the solvent evaporated to give the title compound.

Workup

  1. customwas consumed
  2. customThe cooled reaction mixture
  3. customwas quenched with saturated aqueous sodium potassium tartrate solution
  4. filtrationthe resulting grey solid was filtered off
  5. customThe filtrate was dried
  6. customthe solvent evaporated

Sources & evidence

ORD record
ord-2ef4ad623f584f46a5f885caa4c3fcfe
Source dataset
uspto-grants-1990_04
Patent number
US04914111

Reaction notes

Loading…