(Dimethyl sulfide)trihydroboron → HCID 12945116, compound

HRID 2072773Notes

Reaction equation

HRID 2072773 reaction equation
[CH3:1][C:2]([N:5]1[C:10](=O)[CH2:9][O:8][CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6]1)([CH3:4])[CH3:3].B.CSC>>[CH3:4][C:2]([N:5]1[CH2:10][CH2:9][O:8][CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6]1)([CH3:1])[CH3:3]

Participants

3

Reactant 2

HCID 12423031(Dimethyl sulfide)trihydroboronHCID 19913608HCID 19913608, compound

Product 1

HCID 12945116HCID 12945116, compound

Procedure

4-[1,1-Dimethylethyl]-2-phenylmorpholine was prepared from 4-[1,1-dimethylethyl]-5-oxo-2-phenylmorpholine and borane-methyl sulphide by an analogous procedure to that described in Example 1. After purification by column chromatography on silica using 0->8% methanol in dichloromethane as eluant, the resultant oil was converted to its hydrochloride salt, m.p. 208°-210° C., (ethyl acetate).

Workup

  1. customAfter purification by column chromatography on silica using 0->8% methanol in dichloromethane as eluant

Sources & evidence

ORD record
ord-a5632580c4b94e75a04df07db6777fcb
Source dataset
uspto-grants-1990_04
Patent number
US04914202

Reaction notes

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