Thionyl Chloride → HCID 19860557, compound

HRID 2072795Notes

Reaction equation

HRID 2072795 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:11]([OH:13])=O)[CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>>[ClH:16].[Cl:16][C:11]([C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[N:1]=[CH:2][CH:3]=[CH:4]2)=[O:13]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 665828-Quinolinecarboxylic acid

Product 1

HCID 19860557HCID 19860557, compound

Procedure

Quinoline-8-carboxylic acid (1.0 g) was added to 3 ml of thionyl chloride, and the reaction mixture heated at reflux for one hour. The reaction mixture was allowed to stir at room temperature and was then concentrated in vacuo. The residue was washed with benzene (2×10 ml) and was used in the next reaction.

Workup

  1. temperaturethe reaction mixture heated
  2. temperatureat reflux for one hour
  3. concentrationwas then concentrated in vacuo
  4. washThe residue was washed with benzene (2×10 ml)
  5. customwas used in the next reaction

Sources & evidence

ORD record
ord-914d65e7d5ff476895ebb0ec9e220fd1
Source dataset
uspto-grants-1990_04
Patent number
US04914207

Reaction notes

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