反应详情

温度

120 °C

The compound 1-methanesulfonyloxy-2,2-difluoro-4-benzyloxybutane (21.8 g 74.1 mM), dry DMF (100 mL), and potassium phthalimide (15.26 g, 10% excess) are stirred and heated under nitrogen, at 120° C. for 5 days. Following the addition of water (500 mL), the mixture is extracted with ether. The organic phase is washed with 1N CCl followed by water (twice), dried (Na2SO4) and concentrated to a volume of about 100 mL. Upon addition of petroleum ether, crystallization occurs. After chilling for 3 hours at 5° C., beige crystals of the compound N-(4-benzyloxy-2,2-difluorobutyl)phthalimide are obtained, filtered and washed with petroleum ether: 18 g (70%).

1. extractionthe mixture is extracted with ether
2. washThe organic phase is washed with 1N CCl
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated to a volume of about 100 mL
5. additionUpon addition of petroleum ether, crystallization
6. temperatureAfter chilling for 3 hours at 5° C.