Hydrochloric Acid → HCID 23037407, compound

HRID 2072962Notes

Reaction equation

HRID 2072962 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]([CH2:17][C:18]([NH:20][CH2:21][CH2:22][N:23]([CH3:25])[CH3:24])=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.Cl>CC(C)=O>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]([CH2:17][C:18]([NH:20][CH2:21][CH2:22][N:23]([CH3:25])[CH3:24])=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14390214HCID 14390214, compound

Product 1

HCID 23037407HCID 23037407, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-(4-Chlorophenyl)-N-[2-(dimethylamino)ethyl]-3H-imidazo[4,5-b]pyridine-3-acetamide (0.5 g, 0.0014 mole) was dissolved in acetone, acidified with ethanolic hydrogen chloride, and seeded to initiate crystallization. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum at room temperature overnight to give 0.60 g (quantitative yield), m.p. 222°-25° C.

Workup

  1. customcrystallization
  2. filtrationThe solid was collected by filtration
  3. washwashed with diethyl ether
  4. customdried under high vacuum at room temperature overnight
  5. customto give 0.60 g (quantitative yield), m.p. 222°-25° C.

Sources & evidence

ORD record
ord-5d54449c0f4447849adfeab3a1ba0436
Source dataset
uspto-grants-1990_04
Patent number
US04914109

Reaction notes

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