Water → HCID 19857817, compound

HRID 2073164Notes

Reaction equation

HRID 2073164 reaction equation
[C:1]1(=O)[N:6]([CH2:7][CH2:8][CH2:9][N:10]2[C:18]3=[N:19][C:20]4[C:25]([N:26]=[C:17]3[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]2=3)=[CH:24][CH:23]=[CH:22][CH:21]=4)[C:5](=O)[CH2:4][CH2:3][CH2:2]1.[Li].O>O1CCCC1>[N:6]1([CH2:7][CH2:8][CH2:9][N:10]2[C:18]3=[N:19][C:20]4[C:25]([N:26]=[C:17]3[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]2=3)=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 962WaterHCID 3028194LithiumHCID 19857816HCID 19857816, compound

Product 1

HCID 19857817HCID 19857817, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6-(3-glutarimidopropyl)-6H-indolo(2,3-b)quinoxaline (3.72 g) is heated under reflux with lithium aluminumhydride (0.80 g) in tetrahydrofuran (40 ml) for 6 hours, and then water (2 ml) is dropped thereto carefully. After stirring for 1 hour solid material is separated away and the residue is concentrated. The residue is dissolved in dry ether and the base is precipitated as hydrochloride by addition of hydrogen chloride. Yield: 2.60 g (68%), mp. 262°-266° C.

Workup

  1. customis separated away
  2. concentrationthe residue is concentrated
  3. dissolutionThe residue is dissolved in dry ether
  4. customthe base is precipitated as hydrochloride by addition of hydrogen chloride

Sources & evidence

ORD record
ord-bb459292d6b844f7be3d1e202e8fe97b
Source dataset
uspto-grants-1990_04
Patent number
US04916124

Reaction notes

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