反应详情

A solution of 14.7 g (60 mmol) of (S)-3-azido-1-pyrrolidinecarboxylic acid, phenylmethyl ester in 200 ml of methanol was treated with 1.0 g of Raney-nickel and shaken in a hydrogen atmosphere at pressures of 49.5-51 psi and temperatures of 25.3-29.5° for nine hours. The catalyst was removed by filtration and the solvent was removed in vacuo to give 13.2 g of the title compound.

1. customThe catalyst was removed by filtration
2. customthe solvent was removed in vacuo