HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 14555476, compound → (S)-1-Cbz-3-Aminopyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 14555476 | HCID 14555476 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-1-Cbz-3-Aminopyrrolidine | HCID 1519355 | 99.9% |
Reaction Steps
A solution of 14.7 g (60 mmol) of (S)-3-azido-1-pyrrolidinecarboxylic acid, phenylmethyl ester in 200 ml of methanol was treated with 1.0 g of Raney-nickel and shaken in a hydrogen atmosphere at pressures of 49.5-51 psi and temperatures of 25.3-29.5° for nine hours. The catalyst was removed by filtration and the solvent was removed in vacuo to give 13.2 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04916141 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-8b2f28a8ca7546a98cfefefd9d3c87dd |
| Source note | uspto-grants-1990_04 |