Methanol → HCID 23365355, compound

HRID 2073182Notes

Reaction equation

HRID 2073182 reaction equation
[Br:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][O:7][C:8]2[CH:15]=[CH:14][C:11]([C:12]#N)=[CH:10][C:9]=2[CH:16]([N:20]2[CH:24]=[CH:23][N:22]=[CH:21]2)[CH2:17][CH2:18][CH3:19])=[CH:4][CH:3]=1.[OH-:27].[K+].C[OH:30]>>[Br:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][O:7][C:8]2[CH:15]=[CH:14][C:11]([C:12]([OH:30])=[O:27])=[CH:10][C:9]=2[CH:16]([N:20]2[CH:24]=[CH:23][N:22]=[CH:21]2)[CH2:17][CH2:18][CH3:19])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 23365288HCID 23365288, compound

Product 1

HCID 23365355HCID 23365355, compound

Procedure

1.5 g of 4-(4-bromobenzyloxy)-3-[1-(1-imidazolyl)butyl]-benzonitrile (of example 3) is reacted with 3 g of potassium hydroxide in an aqueous methanol solution for 24 hours under reflux. After working up, 1.1 g of 4-(4-bromobenzyloxy)-3-[1-(1-imidazolyl)-butyl]-benzoic acid with a melting point of 187°-189° C. is obtained.

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-0183e6af9d494b769526e7244658b8d9
Source dataset
uspto-grants-1990_04
Patent number
US04916144

Reaction notes

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