Sulfuric Acid → HCID 15042086, compound

HRID 2073210Notes

Reaction equation

HRID 2073210 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]3[N:14]=[CH:15][C:16]([C:17]#[N:18])=[C:12]3[N:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.S(=O)(=O)(O)[OH:20].[OH-].[NH4+]>>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]3[N:14]=[CH:15][C:16]([C:17]([NH2:18])=[O:20])=[C:12]3[N:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 4773657HCID 4773657, compound

Product 1

HCID 15042086HCID 15042086, compound

Procedure

A mixture of 7-(3-methylphenyl)pyrazolo[1,5-a]-pyrimidine-3-carbonitrile (prepared as described in Example 7 of U.S. Pat. No. 4,236,005) and concentrated sulfuric acid is stirred at room temperature for 16 hours. The solution is then carefully poured into ice with stirring and mixture is carefully made just basic with concentrated ammonium hydroxide. The solid is collected by filtration to give 7-(3-methylphenyl) pyrazolo[1,5-a]pyrimidine-3-carboxamide.

Workup

  1. customprepared
  2. additionThe solution is then carefully poured into ice
  3. filtrationThe solid is collected by filtration

Sources & evidence

ORD record
ord-c50bd67949b0465abebe1017e08d6a18
Source dataset
uspto-grants-1990_04
Patent number
US04916137

Reaction notes

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