HCID 14570084, compound → HCID 14570085, compound

HRID 2073297Notes

Reaction equation

HRID 2073297 reaction equation
C1(C[O:8][C:9]2[CH:10]=[C:11]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]4[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=4)=[O:22])=[CH:17][CH:16]=3)[CH:12]=[CH:13][CH:14]=2)C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]3[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=3)=[O:22])=[CH:19][CH:20]=2)[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 14570084HCID 14570084, compound

Product 1

HCID 14570085HCID 14570085, compoundYield 58.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 7.8 g of 3'-(phenylmethoxy)-N-[4-(3-pyridinyl)butyl][1,1'-biphenyl]-4-carboxamide in 150 mL of ethanol was hydrogenated over 0.8 g of 10% palladium on carbon. The product was crystallized from acetonitrile to give 3.6 g of 3'-hydroxy-N-[4-(3-pyridinyl)butyl][1,1'-biphenyl]-4-carboxamide mp 150°-151.5° C. The analytical sample was obtained from acetonitrile, mp 151.5°-152.5° C.

Workup

  1. customThe product was crystallized from acetonitrile

Sources & evidence

ORD record
ord-16c671e31b2e41be9908a3beae5d421a
Source dataset
uspto-grants-1990_04
Patent number
US04916145

Reaction notes

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