Methylamine → HCID 136084615, compound

Participants

Reaction Steps

A flask provided with a stirrer is loaded with 1.23 g (3.5 mmole) of 9-[2-(2-tetrahydropyranyloxy)ethoxymethyl]-N2 -acetylguanine obtained as described in Example 3 and 20 ml of a 25 percent aqueous solution of methylamine are added. The reaction mixture is stirred at room temperature for 2 hours and evaporated in vacuum at a temperature not above 30° C. The dray residue is recrystallized from an aqueous soluton of ethyl alcohol to give 0.86 g (80 percent) of 9-[2-(2-tetrahydropyranyloxy)ethoxymethyl]guanine.

Provenance & Evidence