Methylamine → HCID 136084615, compound

HRID 2073329Notes

Reaction equation

HRID 2073329 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][O:10][CH2:11][N:12]1[CH:20]=[N:19][C:18]2[C:17](=[O:21])[NH:16][C:15]([NH:22]C(=O)C)=[N:14][C:13]1=2.CN>>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][O:10][CH2:11][N:12]1[CH:20]=[N:19][C:18]2[C:17](=[O:21])[NH:16][C:15]([NH2:22])=[N:14][C:13]1=2

Participants

3

Reactant 2

HCID 6329MethylamineHCID 135962070HCID 135962070, compound

Product 1

HCID 136084615HCID 136084615, compoundYield 80%

Procedure

A flask provided with a stirrer is loaded with 1.23 g (3.5 mmole) of 9-[2-(2-tetrahydropyranyloxy)ethoxymethyl]-N2 -acetylguanine obtained as described in Example 3 and 20 ml of a 25 percent aqueous solution of methylamine are added. The reaction mixture is stirred at room temperature for 2 hours and evaporated in vacuum at a temperature not above 30° C. The dray residue is recrystallized from an aqueous soluton of ethyl alcohol to give 0.86 g (80 percent) of 9-[2-(2-tetrahydropyranyloxy)ethoxymethyl]guanine.

Workup

  1. customA flask provided with a stirrer
  2. customobtained
  3. additionare added
  4. customevaporated in vacuum at a temperature not above 30° C
  5. customThe dray residue is recrystallized from an aqueous soluton of ethyl alcohol

Sources & evidence

ORD record
ord-0c7512d98006477f970dac746edaea5c
Source dataset
uspto-grants-1990_04
Patent number
US04916225

Reaction notes

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