Bromine → HCID 19858071, compound

HRID 2073389Notes

Reaction equation

HRID 2073389 reaction equation
[Br:1]Br.O[C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][C:8]([CH3:14])=[CH:9][CH:10]=2)[C:5]=1[CH2:15][C:16]([OH:18])=[O:17]>C(O)(=O)C>[Br:1][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[CH3:14])[C:5]1[CH2:15][C:16](=[O:17])[O:18][C:4]=1[CH:13]=[CH:12]2

Participants

4

Reactant 2

HCID 24408BromineHCID 54424481HCID 54424481, compound

Product 1

HCID 19858071HCID 19858071, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A solution of bromine (0.05 ml) in acetic acid (2 ml) was added over 5 minutes to a solution of 2-hydroxy-7-methyl-1-naphthylacetic acid (0.21 g) in acetic acid (5 ml). The solid which precipitated was collected and washed with acetic acid to give 7-bromo-8-methyl-2(1H)-naphtho[2,1-b]furanone, m.p. 238°-240°.

Workup

  1. customThe solid which precipitated
  2. customwas collected
  3. washwashed with acetic acid

Sources & evidence

ORD record
ord-a94175d01793431a86413bf52d98c224
Source dataset
uspto-grants-1990_04
Patent number
US04916148

Reaction notes

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