Acetonitrile → HCID 19858044, compound

HRID 2073391Notes

Reaction equation

HRID 2073391 reaction equation
Cl[CH:2]([C:10]1[CH:22]=[C:21]2[C:13]([CH:14]=[CH:15][C:16]3[O:17][C:18](=[O:25])[C:19](C)(C)[C:20]=32)=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][CH:4]=1.[NH:26]1[CH:30]=[N:29][CH:28]=[N:27]1.C(=O)([O-])[O-].[K+].[K+].C(#N)C>O>[Cl:9][C:6]1[CH:7]=[CH:8][C:3]([CH:2]([C:10]2[CH:22]=[C:21]3[C:13]([CH:14]=[CH:15][C:16]4[O:17][C:18](=[O:25])[CH2:19][C:20]=43)=[CH:12][CH:11]=2)[N:26]2[CH:30]=[N:29][CH:28]=[N:27]2)=[CH:4][CH:5]=1

Participants

6

Reactant 4

HCID 6342AcetonitrileHCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 19858036HCID 19858036, compound

Product 1

HCID 19858044HCID 19858044, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 8-(α,4-dichlorobenzyl)-1,1-dimethyl-2(1H)-naphtho[2,1-b]furanone, 1,2,4-triazole (0.3 g), potassium carbonate (0.3 g) and acetonitrile (5 ml) was heated under reflux for 18 h. The mixture was treated with water (20 ml) and extracted with ethyl acetate. The ethyl acetate extract was dried and then evaporated to dryness, and the residue was purified by flash chromatography eluting with methanol:chloroform, 1:99 v/v, to give 8-[4-chloro-α-(1H-1,2,4-triazol-1-yl)benzyl]-2(1H)-naphtho[2,1-b]furanone. Nmr in deuteriochloroform: δ8.12(2H,s); 7.94(1H,d); 7.36-7.46(4H,m); 7.15-7.25(3H,m); 6.92(1H,s); 1.62(3H,s); 1.60(3H,s).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 18 h
  3. extractionextracted with ethyl acetate
  4. extractionThe ethyl acetate extract
  5. customwas dried
  6. customevaporated to dryness
  7. customthe residue was purified by flash chromatography
  8. washeluting with methanol

Sources & evidence

ORD record
ord-093a5c9bfbd44dc2b50e184e2ece372a
Source dataset
uspto-grants-1990_04
Patent number
US04916148

Reaction notes

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