HCID 19857187, compound → HCID 19857167, compound

HRID 2073489Notes

Reaction equation

HRID 2073489 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][CH2:15][CH2:16][CH:17]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[F:31][C:28]1[CH:29]=[CH:30][C:25]([CH:17]([C:18]2[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=2)[CH2:16][CH2:15][CH2:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:26][CH:27]=1

Participants

4

Reactant 1

HCID 19857187HCID 19857187, compound

Product 1

HCID 19857167HCID 19857167, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

17 g (40.7 mmol) of 1-benzyl-4-[4,4-bis(4-fluorophenyl)-butylidene]piperidine were hydrogenated in 850 ml of methanol with 5 g of palladium-on-charcoal (10%) at 45° C. in a shaking vessel for 2 hours. The catalyst was filtered off with suction and the solution was concentrated.

Workup

  1. filtrationThe catalyst was filtered off with suction
  2. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-a7996edd6a2b4c1e969349a076513a33
Source dataset
uspto-grants-1990_04
Patent number
US04918073

Reaction notes

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