Trityl chloride → HCID 13883286, compound

Participants

Reaction Steps

1.29 g (10 mmol) of piperazine-2-carboxamide were dissolved in 20 ml of absolute methylene chloride, 1.01 g (10 mmol) of triethylamine were added, a solution of 2.79 g (10 mmol) of triphenylmethyl chloride in 20 ml of absolute methylene chloride was added dropwise and the mixture was subsequently stirred at room temperature for 5 hours. The reaction solution was washed twice with water, dried and concentrated and the crude product was purified by flash chromatography on silica gel with CH2Cl2 /CH3OH 95:5.

Provenance & Evidence