Trityl chloride → HCID 13883286, compound

HRID 2073494Notes

Reaction equation

HRID 2073494 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH:2]1[C:7]([NH2:9])=[O:8].C(N(CC)CC)C.[C:17]1([C:23](Cl)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(Cl)Cl>[C:23]([N:4]1[CH2:5][CH2:6][NH:1][CH:2]([C:7]([NH2:9])=[O:8])[CH2:3]1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 3019914Piperazine-2-carboxamide

Product 1

HCID 13883286HCID 13883286, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

1.29 g (10 mmol) of piperazine-2-carboxamide were dissolved in 20 ml of absolute methylene chloride, 1.01 g (10 mmol) of triethylamine were added, a solution of 2.79 g (10 mmol) of triphenylmethyl chloride in 20 ml of absolute methylene chloride was added dropwise and the mixture was subsequently stirred at room temperature for 5 hours. The reaction solution was washed twice with water, dried and concentrated and the crude product was purified by flash chromatography on silica gel with CH2Cl2 /CH3OH 95:5.

Workup

  1. washThe reaction solution was washed twice with water
  2. customdried
  3. concentrationconcentrated
  4. customthe crude product was purified by flash chromatography on silica gel with CH2Cl2 /CH3OH 95:5

Sources & evidence

ORD record
ord-7277175777024b108320845b3da0e2d6
Source dataset
uspto-grants-1990_04
Patent number
US04918073

Reaction notes

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