Sodium Hydroxide → HCID 53970677, compound

HRID 2073539Notes

Reaction equation

HRID 2073539 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:41]=[CH:40][C:17]([O:18][CH2:19][C:20]4[CH:39]=[CH:38][CH:37]=[CH:36][C:21]=4[O:22][CH:23]([C:31]([O:33]CC)=[O:32])[CH2:24][CH2:25][C:26]([O:28]CC)=[O:27])=[CH:16][CH:15]=3)=[N:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>O1CCOCC1>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:15]=[CH:16][C:17]([O:18][CH2:19][C:20]4[CH:39]=[CH:38][CH:37]=[CH:36][C:21]=4[O:22][CH:23]([C:31]([OH:33])=[O:32])[CH2:24][CH2:25][C:26]([OH:28])=[O:27])=[CH:40][CH:41]=3)=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70362505HCID 70362505, compound

Product 1

HCID 53970677HCID 53970677, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The crude product is purified by column chromatography to give ethyl 4-(2-(4-(2-(7-chloroquinolin-2-yl)ethenyl)phenoxymethyl)phenoxy)-4-carbethoxybutyrate. The ester is treated with 1N NaOH solution (30 mL) in dioxane overnight. The reaction mixture is then acidified, and purified by flash chromatography which gives 4-(2-(4-(2-(7-chloroquinolin-2-yl)ethenyl)phenoxymethyl)phenoxy)-4-carboxybutyric acid.

Workup

  1. custompurified by flash chromatography which

Sources & evidence

ORD record
ord-bd93f2f0a036448aa4c89aa675cfe30c
Source dataset
uspto-grants-1990_04
Patent number
US04918081

Reaction notes

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