HCID 54466938, compound → HCID 135698649, compound

HRID 2073611Notes

Reaction equation

HRID 2073611 reaction equation
[C:1]([C:4](=[CH:9][C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]([O:7][CH3:8])=[O:6])(=O)[CH3:2].[NH2:15][C:16]1[N:20]=[CH:19][NH:18][N:17]=1>C(O)C>[CH3:8][O:7][C:5]([C:4]1[CH:9]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[N:17]2[N:18]=[CH:19][N:20]=[C:16]2[NH:15][C:1]=1[CH3:2])=[O:6]

Participants

4

Reactant 2

HCID 54466938HCID 54466938, compoundHCID 178418311HCID 178418311, compound

Product 1

HCID 135698649HCID 135698649, compoundYield 44.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 50 g of methyl 2-acetyl-3-(2-thienyl)acrylate, 20 g of 3-amino-1,2,4-triazole and 300 ml of ethanol is heated under reflux for 4 hours. The precipitated white crystals are collected by filtration to give 29.5 g of 6-methoxycarbonyl-5-methyl-7-(2-thienyl)-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine, melting at 239°-240° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 4 hours
  3. filtrationThe precipitated white crystals are collected by filtration

Sources & evidence

ORD record
ord-a05103b283214cb7bc22dfd207842079
Source dataset
uspto-grants-1990_04
Patent number
US04918074

Reaction notes

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