Acetone → HCID 13589485, compound

HRID 2073620Notes

Reaction equation

HRID 2073620 reaction equation
[ClH:1].C[O:3][CH:4](OC)[C:5]1[NH:6][C:7]2[N:8]([CH:25]=[CH:26][N:27]=2)[CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=2)[C:10]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12].CC(C)=O>O>[ClH:1].[CH2:14]([O:13][C:11]([C:10]1[CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=2)[N:8]2[CH:25]=[CH:26][N:27]=[C:7]2[NH:6][C:5]=1[CH:4]=[O:3])=[O:12])[CH3:15]

Participants

5

Reactant 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 13589483HCID 13589483, compound

Product 1

HCID 13589485HCID 13589485, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 ml of 6N hydrochloric acid is added to a solution of 4.4 g of 7-dimethoxymethyl-6-ethoxycarbonyl-5-(3-nitrophenyl)-5,8-dihydroimidazo[1,2-a]pyrimidine in mixture of 10 ml of acetone and 10 ml of water and the mixture is stirred at room temperature for an hour, and then allowed to stand overnight. The solvent is distilled off under reduced pressure below 40° C. to give 4 g of 6-ethoxycarbonyl-7-formyl-5-(3-nitrophenyl)-5,8-dihydroimidazo[1,2-a]pyrimidine hydrochloride, melting at 228° C. with decomposition.

Workup

  1. distillationThe solvent is distilled off under reduced pressure below 40° C.

Sources & evidence

ORD record
ord-5ab330828d324c7b825bd635c04025fd
Source dataset
uspto-grants-1990_04
Patent number
US04918074

Reaction notes

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