Water → HCID 19890426, compound

HRID 2073638Notes

Reaction equation

HRID 2073638 reaction equation
[OH-].[Na+].O.[F:4][C:5]([F:26])([F:25])[CH:6]([CH2:21][CH2:22][CH2:23][CH3:24])[CH2:7][CH2:8][O:9][C:10]1[CH:20]=[CH:19][C:13]([C:14]([O:16]CC)=[O:15])=[CH:12][CH:11]=1>CO>[F:4][C:5]([F:25])([F:26])[CH:6]([CH2:21][CH2:22][CH2:23][CH3:24])[CH2:7][CH2:8][O:9][C:10]1[CH:20]=[CH:19][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 962Water2×HCID 14798Sodium HydroxideHCID 19890431HCID 19890431, compound

Product 1

HCID 19890426HCID 19890426, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

In a round-bottomed flask, 0.27 g of sodium hydroxide and 1 ml of water were placed, 3 ml of methanol was added and then 0.7 g of ethyl p-(3-trifluoromethylheptyloxy)benzoate was added thereto, followed by 4 hours of reaction at 50° C. Then, water was added to the system, and methanol was distilled off, followed by addition of 6N-hydrochloric acid to recover a precipitated crystal. The crystal was dried in a desiccator to obtain 0.55 g of p-(3-trifluoromethylheptyloxy)benzoic acid ◯4 . (Yield: 90%).

Workup

  1. customfollowed by 4 hours of reaction at 50° C
  2. distillationwas distilled off
  3. additionfollowed by addition of 6N-hydrochloric acid
  4. customto recover a precipitated crystal
  5. customThe crystal was dried in a desiccator

Sources & evidence

ORD record
ord-b2eafc0542ea40e4a2519d91811c0e04
Source dataset
uspto-grants-1990_04
Patent number
US04918213

Reaction notes

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