Hydrochloric Acid → HCID 18638689, compound

Participants

Reaction Steps

36.4 g (0.2 mole) 4-bromobenzonitrile, 29.8 g (0.2 mole) D-penicillamine and 13.8 g (0.1 mole) potassium carbonate were heated in 350 ml methanol and 150 ml water for 6 hours at the boiling point. After the mixture was acidified with concentrated hydrochloric acid to pH 4, it was heated one hour to a boil. After it cooled off, 53.6 g (81% of theory) of the product were isolated as a colorless precipitate with a melting point of 176° C.

Provenance & Evidence