Water → HCID 14402941, compound

HRID 2073661Notes

Reaction equation

HRID 2073661 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]#[N:8].O.Cl.N[CH:12]([C:15]([OH:17])=[O:16])[CH2:13][SH:14].C(=O)([O-])[O-:19].[K+].[K+].O>CO>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:8][CH:12]([C:15]([OH:17])=[O:16])[CH2:13][SH:14])=[O:19]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 728802-ThienylacetonitrileHCID 12219647DL-CYSTEINE HYDROCHLORIDE MONOHYDRATE

Product 1

HCID 14402941HCID 14402941, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

24.6 g (0.2 mole) thiophene-2-acetonitrile, 35.2 g (0.2 mole) D,L-cysteine hydrochloride monohydrate and 27.6 g (0.2 mole) potassium carbonate were heated in 500 ml methanol and 250 ml water for 6 hours at the boiling point. Then the solvent was removed under reduced pressure, the residue taken up in 200 ml water and adjusted with concentrated hydrochloric acid to pH 4. 40.8 g (83% of theory) colorless product with a melting point of 138°-140° C. precipitated.

Workup

  1. customThen the solvent was removed under reduced pressure
  2. custom40.8 g (83% of theory) colorless product with a melting point of 138°-140° C. precipitated

Sources & evidence

ORD record
ord-f8ebed496e77488d909e0899f9399293
Source dataset
uspto-grants-1990_04
Patent number
US04918223

Reaction notes

Loading…