Potassium Hydroxide → HCID 85566136, compound

HRID 2073721Notes

Reaction equation

HRID 2073721 reaction equation
[OH-:1].[K+].Cl.[NH2:4]O.[CH2:6]([N:8]([CH2:22][CH3:23])[CH2:9][C:10]([C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1)=O)[CH3:7]>CO.O>[CH2:6]([N:8]([CH2:22][CH3:23])[CH2:9][C:10]([C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1)=[N:4][OH:1])[CH3:7]

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 15057236HCID 15057236, compound

Product 1

HCID 85566136HCID 85566136, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

To a cooled solution of 97.6 g (1.48 mol) of potassium hydroxide in 320 mL of methanol add a solution of 20.8 g (0.3 mol) of hydroxylamine hydrochloride in 48 mL of water at 20° C. To this basic solution add a solution of 16 g (0.064 mol) of 2-(diethylamino)-1-(naphthalen-1-yl)ethanone in 20.8 mL of methanol at 20° C. Stir the reaction mixture overnight. The reaction mixture is concentrated in vacuo. Add methylene chloride and extract with 3×200 mL of water. Dry the organic layer over sodium sulfate. Remove the solvent in vacuo to obtain the title compound.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. extractionAdd methylene chloride and extract with 3×200 mL of water
  3. dry with materialDry the organic layer over sodium sulfate
  4. customRemove the solvent in vacuo

Sources & evidence

ORD record
ord-d429dcea602e4a8b9517b57d478a280c
Source dataset
uspto-grants-1990_04
Patent number
US04920116

Reaction notes

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