2',4'-Dichloroacetophenone → 2-Bromo-1-(2,4-dichlorophenyl)ethan-1-one

HRID 2073737Notes

Reaction equation

HRID 2073737 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[Br:12]Br>C(OCC)C>[Br:12][CH2:10][C:9]([C:3]1[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=1[Cl:1])=[O:11]

Participants

4

Reactant 2

HCID 166932',4'-DichloroacetophenoneHCID 24408Bromine

Product 1

HCID 758282-Bromo-1-(2,4-dichlorophenyl)ethan-1-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 100 mL of ethyl ether is added 1-(2,4-dichlorophenyl)ethanone (18.9 g, 0.1 mol) and bromine (16 g, 0.1 mmol). Monitor the reaction by thin-layer chromatography. Upon completion wash the organic phase with 100 mL H2O and 50 mL brine. Dry the organic phase over Na2SO4. Filter the drying agent and evaporate the solvent in vacuo to obtain the title compound.

Workup

  1. customMonitor the reaction by thin-layer chromatography
  2. washUpon completion wash the organic phase with 100 mL H2O and 50 mL brine
  3. dry with materialDry the organic phase over Na2SO4
  4. filtrationFilter the drying agent
  5. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-702fed60d9b9440c8f94e1ebe74d7a9f
Source dataset
uspto-grants-1990_04
Patent number
US04920116

Reaction notes

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