HCID 19855899, compound → HCID 19855943, compound

HRID 2073759Notes

Reaction equation

HRID 2073759 reaction equation
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:23][CH2:24][N:25]([CH2:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)CC2C=CC=CC=2)[C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1>[Pd].C(O)C>[ClH:1].[F:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]([CH2:23][CH2:24][NH:25][CH2:33][CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:10](=[O:22])[C:11]2[CH:12]=[CH:13][C:14]([NH:17][S:18]([CH3:21])(=[O:19])=[O:20])=[CH:15][CH:16]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 19855899HCID 19855899, compound

Product 1

HCID 19855943HCID 19855943, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Hydrogenate N-(4-fluorophenyl)-4-[(methylsulfonyl)amino]-N-[2-[(2-phenylethyl)(phenylmethyl)amino]ethyl]benzamide hydrochloride over palladium on carbon in ethanol at 30-40 psi. Follow the progress of the reaction by thinlayer chromatography on silica gel. At the completion of the reaction remove the catalyst by filtration and evaporate the solvent in vacuo to obtain the title compound.

Workup

  1. customthe progress of the reaction by thinlayer chromatography on silica gel
  2. customAt the completion of the reaction remove the catalyst
  3. filtrationby filtration
  4. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-3bfc42208e98411c9c1ff6dfbd513b9e
Source dataset
uspto-grants-1990_04
Patent number
US04920116

Reaction notes

Loading…