Sodium Bicarbonate → HCID 135745117, compound

Participants

Reaction Steps

639 mg of 3-amino-2-phenyl-4-pyridinecarboxamide in 7 ml of concentrated hydrochloric acid were stirred in an ice-bath during the addition of 240 mg of sodium nitrite in 2 ml of water. After 0.5 hour aqueous sodium bicarbonate solution was added until the mixture was basic and the produce was then extracted into ethyl acetate. The ethyl acetate extract was dried over sodium sulphate and evaporated, and the residue was recrystallized from ethanol to yield 420 mg of 8-phenylpyrido[3,4-d]-1,2,3-triazin-4(3H)-one of melting point 211° C. (dec.)

Provenance & Evidence