Sodium Bicarbonate → HCID 135745117, compound

HRID 2073766Notes

Reaction equation

HRID 2073766 reaction equation
[NH2:1][C:2]1[C:3]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:4][CH:5]=[CH:6][C:7]=1[C:8]([NH2:10])=[O:9].[N:17]([O-])=O.[Na+].C(=O)(O)[O-].[Na+]>Cl.O>[C:11]1([C:3]2[C:2]3[N:1]=[N:17][NH:10][C:8](=[O:9])[C:7]=3[CH:6]=[CH:5][N:4]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

6

Reactant 3

HCID 516892Sodium BicarbonateHCID 21957378HCID 21957378, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 135745117HCID 135745117, compoundYield 62.5%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

639 mg of 3-amino-2-phenyl-4-pyridinecarboxamide in 7 ml of concentrated hydrochloric acid were stirred in an ice-bath during the addition of 240 mg of sodium nitrite in 2 ml of water. After 0.5 hour aqueous sodium bicarbonate solution was added until the mixture was basic and the produce was then extracted into ethyl acetate. The ethyl acetate extract was dried over sodium sulphate and evaporated, and the residue was recrystallized from ethanol to yield 420 mg of 8-phenylpyrido[3,4-d]-1,2,3-triazin-4(3H)-one of melting point 211° C. (dec.)

Workup

  1. extractionthe produce was then extracted into ethyl acetate
  2. extractionThe ethyl acetate extract
  3. dry with materialwas dried over sodium sulphate
  4. customevaporated
  5. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-1abfd0d0c46544a6b55bfd02229b9654
Source dataset
uspto-grants-1990_04
Patent number
US04920119

Reaction notes

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