反应详情

A solution of 6.5 g hydroxylamine hydrochloride in 25 ml water was added to a suspension of 18.7 g 2-chloro-6-methoxy-3-quinolinecarboxaldehyde in 500 ml 95% ethanol. The mixture was stirred at room temperature for two hours and then heated at reflux for three hours. The reaction mixture was cooled to 0° C., filtered, and the filtrate concentrated to a volume of 200 ml. The product separated from solution to give 16.3 g 2-chloro-6-methoxy-3-quinolinecarboxaldehyde oxime, m.p. 195° C. (decompn.).

1. temperatureheated
2. temperatureat reflux for three hours
3. temperatureThe reaction mixture was cooled to 0° C.
4. filtrationfiltered
5. concentrationthe filtrate concentrated to a volume of 200 ml
6. customThe product separated from solution