Hydrochloric Acid → HCID 178487367, compound

HRID 2073789Notes

Reaction equation

HRID 2073789 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]3[C:15](N)=[N:14][NH:13][C:9]3=[N:10]2)=[CH:5][CH:4]=1.[ClH:17]>>[Cl:17][C:15]1[C:8]2[C:9](=[N:10][C:11]3[C:6]([CH:7]=2)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=3)[NH:13][N:14]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178487377HCID 178487377, compound

Product 1

HCID 178487367HCID 178487367, compoundYield 25%

Procedure

3-Chloro-7-methoxy-1H-pyrazolo[3,4-b]quinoline was prepared from 7-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine (Example 3d) by diazotization in hydrochloric acid. The product was recrystallized from ethanol and then from acetic acid and obtained in about 25% yield as a brown solid, m.p. 296°-297° C.

Workup

  1. customThe product was recrystallized from ethanol
  2. customfrom acetic acid and obtained in about 25% yield as a brown solid, m.p. 296°-297° C.

Sources & evidence

ORD record
ord-bc9824871a7a42d597fbceeb32be15cf
Source dataset
uspto-grants-1990_04
Patent number
US04920128

Reaction notes

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