Isopropyl iodide → HCID 19856144, compound

HRID 2073791Notes

Reaction equation

HRID 2073791 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]3[C:15]([NH2:16])=[N:14][NH:13][C:9]3=[N:10]2)=[CH:5][CH:4]=1.I[CH:18]([CH3:20])[CH3:19].[H-].[Na+]>>[CH:18]([N:13]1[C:9]2=[N:10][C:11]3[C:6]([CH:7]=[C:8]2[C:15]([NH2:16])=[N:14]1)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=3)([CH3:20])[CH3:19]

Participants

4

Reactant 3

HCID 6362Isopropyl iodideHCID 24758Sodium hydrideHCID 178487377HCID 178487377, compound

Product 1

HCID 19856144HCID 19856144, compound

Procedure

The intermediate 1-isopropyl-7-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine was prepared by alkylation of 7-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine (Example 3d) with 2-iodopropane in the presence of sodium hydride.

Sources & evidence

ORD record
ord-57ff655b202f4ab88cadadd8e41ae439
Source dataset
uspto-grants-1990_04
Patent number
US04920128

Reaction notes

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