Acetic Acid → 2-Methyl-6-ureidobenzyl alcohol

HRID 2073796Notes

Reaction equation

HRID 2073796 reaction equation
[O-:1][C:2]#[N:3].[K+].[NH2:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[C:7]=1[CH2:8][OH:9].C(O)(=O)C>O>[CH3:14][C:10]1[CH:11]=[CH:12][CH:13]=[C:6]([NH:5][C:2]([NH2:3])=[O:1])[C:7]=1[CH2:8][OH:9]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 11378442Potassium cyanateHCID 15339417(2-Amino-6-methylphenyl)methanol

Product 1

HCID 143684562-Methyl-6-ureidobenzyl alcoholYield 73.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of potassium cyanate (1.62 g) in water (5 ml) was added dropwise to a mixture of 2-amino-6-methylbenzyl alcohol (1.37 g), water (5 ml), and acetic acid (6 ml) at room temperature. After being stirred for 2.5 hours, the resulting precipitates were collected by filtration, washed with water, and dried to give 2-methyl-6-ureidobenzyl alcohol (1.33 g).

Workup

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-d46755e0e6a64c30bf1e71ec7bde811e
Source dataset
uspto-grants-1990_04
Patent number
US04920129

Reaction notes

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