HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Methyl-6-methoxycarbonylaminobenzyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Methyl (2-(hydroxymethyl)-3-methylphenyl)carbamate | HCID 14368454 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Methyl-6-methoxycarbonylaminobenzyl chloride | HCID 14368480 | — |
Reaction Steps
To a suspension of 2-methyl-6-methoxycarbonylaminobenzyl alcohol (29.19 g) in methylene chloride (290 ml) was added dropwise thionyl chloride (11.46 ml) at room temperature and the resultant mixture was stirred for 2 hours. After the solvent was evaporated in vacuo, n-hexane was added to the residue to give precipitates. The precipitates were collected by filtration and dried to give 2-methyl-6-methoxycarbonylaminobenzyl chloride (28.26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920129 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-eed79d116bc74f719df6ac07aac571a7 |
| Source note | uspto-grants-1990_04 |