HCID 14499846, compound → HCID 14499848, compound

HRID 2073808Notes

Reaction equation

HRID 2073808 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:24](=[O:30])[CH2:25][O:26]C(=O)C)[C:3]=1[CH2:4][NH:5][C:6]1[C:7]2[N:8]([C:12]([CH2:16][C:17]#[CH:18])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1>C(=O)([O-])[O-].[Na+].[Na+].CO.O>[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:24](=[O:30])[CH2:25][OH:26])[C:3]=1[CH2:4][NH:5][C:6]1[C:7]2[N:8]([C:12]([CH2:16][C:17]#[CH:18])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1

Participants

5

Reactant 1

HCID 14499846HCID 14499846, compound

Product 1

HCID 14499848HCID 14499848, compoundYield 98.1%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 10340Sodium CarbonateSolvent

Procedure

8-[2Methyl-6-(2-acetoxyacetyl)aminobenzylamino]3-(2-propynyl)-2 -methylimidazo[1,2-a]pyridine (0.33 g) was dissolved in a mixture of an aqueous solution (0.7 ml) of sodium carbonate (0.0118 g) and methanol (6.6 ml) at room temperature and then the mixture was stirred for 4 hours. The mixture was diluted with water and the resultant solid was collected to give 8-[2-methyl- 6-(2-hydroxyacetyl)aminobenzylamino]-3-(2-propynyl)-2-methylimidazo[1,2-a]pyridine (0.29 g).

Workup

  1. customthe resultant solid was collected

Sources & evidence

ORD record
ord-524da66d424c4a6a99c1fc091896da76
Source dataset
uspto-grants-1990_04
Patent number
US04920129

Reaction notes

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