Hydrochloric Acid → HCID 19856154, compound

HRID 2073810Notes

Reaction equation

HRID 2073810 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:24]([O:26][CH3:27])=[O:25])[C:3]=1[CH2:4][NH:5][C:6]1[C:7]2[N:8]([C:12]([CH2:16][C:17]#[CH:18])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1.[ClH:28]>CO>[ClH:28].[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:24]([O:26][CH3:27])=[O:25])[C:3]=1[CH2:4][NH:5][C:6]1[C:7]2[N:8]([C:12]([CH2:16][C:17]#[CH:18])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 144998258-(2-Methyl-6-methoxycarbonylaminobenzylamino)-3-(2-propynyl)-2-methylimidazo[1,2-a]pyridine

Product 1

HCID 19856154HCID 19856154, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 8-(2-methyl-6-methoxycarbonylaminobenzylamino)-3-(2-propynyl)-2-methylimidazo[1,2-a]pyridine (0.5 g) in methanol (23 ml) was added dropwise 20%-ethanolic hydrogen chloride (0.5 ml) at 5°-10° C. and the mixture was stirred for 1 hour. A solid was collected to give 8-(2-methyl-6-methoxycarbonylaminobenzylamino)-3-(2-propynyl)-2-methylimidazo[1,2-a]pyridine hydrochloride (0.27 g).

Workup

  1. customA solid was collected

Sources & evidence

ORD record
ord-dde8a42e993a4707aa711264162c07f9
Source dataset
uspto-grants-1990_04
Patent number
US04920129

Reaction notes

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