HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperazine → Grepafloxacin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperazine | HCID 66057 | — |
| Reactant | 1-Cyclopropyl-6,7-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 14651254 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Grepafloxacin | HCID 72474 | 43.6% |
Reaction Steps
A mixture of 0.75 g (2.68 mmol) of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid, 1.07 g (10.4 mmol) of 2-methylpiperazine and 30 ml of acetonitrile was refluxed for five hours, then stirred at room temperature overnight. The precipitate was filtered, washed with water/ethanol and acetonitrile, and dried to give 0.42 g of the title compound, mp 189°-192° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920120 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-56fe2994dcfa4c13810f6276e92a910c |
| Source note | uspto-grants-1990_04 |