反应详情

A suspension of 0.38 g (1.21 mmol) of 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid, 0.42 g (4.88 mmol) of piperazine and 20 ml of acetonitrile was refluxed for four hours, then stirred at room temperature overnight. The precipitate was filtered and washed with water and acetonitrile to give 0.32 g of the title compound, mp 234°-235° C.

1. temperaturewas refluxed for four hours
2. filtrationThe precipitate was filtered
3. washwashed with water and acetonitrile