Piperazine → HCID 14651219, compound

HRID 2073850Notes

Reaction equation

HRID 2073850 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([CH3:16])[C:9]([F:15])=[C:10](F)[C:11]=2[F:13])[C:6](=[O:17])[C:5]([C:18]([OH:20])=[O:19])=[CH:4]1)[CH3:2].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(#N)C>[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([CH3:16])[C:9]([F:15])=[C:10]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[C:11]=2[F:13])[C:6](=[O:17])[C:5]([C:18]([OH:20])=[O:19])=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 14651268HCID 14651268, compound

Product 1

HCID 14651219HCID 14651219, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 0.45 g (1.58 mmol) of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid, 0.54 g (6.27 mmol) of anhydrous piperazine, and 20 ml of acetonitrile was refluxed for three hours, then cooled to room temperature. The solids were filtered and washed with water, acetonitrile, and ether to give 0.48 g of the title compound, mp 223°-225° C.

Workup

  1. temperaturewas refluxed for three hours
  2. filtrationThe solids were filtered
  3. washwashed with water, acetonitrile, and ether

Sources & evidence

ORD record
ord-635a42aafa5c4ee4b93cfe862d74b005
Source dataset
uspto-grants-1990_04
Patent number
US04920120

Reaction notes

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