Morpholine → HCID 1471731, compound

HRID 2073858Notes

Reaction equation

HRID 2073858 reaction equation
[C:1]([C:4]1[C:5]([CH3:13])=[N:6][C:7](Cl)=[C:8]([C:10]#[N:11])[CH:9]=1)(=[O:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>C1(C)C=CC=CC=1>[C:1]([C:4]1[C:5]([CH3:13])=[N:6][C:7]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[C:8]([C:10]#[N:11])[CH:9]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 14753755-acetyl-2-chloro-6-methylnicotinonitrile

Product 1

HCID 1471731HCID 1471731, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
90 °C

Procedure

9.5 g (48.8 mmol) of 3-acetyl-6-chloro-5-cyano-2-methyl-pyridine are dissolved in 180 ml of toluene, 9.5 g (0.109 mol) of morpholine are added, and the mixture is stirred at 90° C. for two hours. To work up, the mixture is evaporated, and the residue is suspended in water, filtered with suction and carefully washed with water. Re-crystallization from methanol/water is used for purification.

Workup

  1. customthe mixture is evaporated
  2. filtrationfiltered with suction
  3. washcarefully washed with water
  4. customRe-crystallization from methanol/water is used for purification

Sources & evidence

ORD record
ord-5d5bc7643f544456ae4125dbf90c803d
Source dataset
uspto-grants-1990_04
Patent number
US04920136

Reaction notes

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